Small Research Grants for Analyses of Gabriella Miller Kids First Pediatric Research Data (R03 Clinical Trial Not Allowed) | PAR 19 375

Opportunity Information: Apply for PAR 19 375

This NIH funding opportunity (PAR-19-375) is a discretionary grant mechanism using the R03 small research grant format, and it is specifically marked as "Clinical Trial Not Allowed." It comes out of the NIH Common Fund and centers on the Gabriella Miller Kids First Pediatric Research Program (Kids First), a national effort designed to accelerate discoveries in pediatric disease by building a large, shared research data resource. The program focuses on generating and organizing genome sequence data alongside phenotypic and clinical information, with the aim of supporting investigators who study the genetics of childhood cancers and structural birth defects. The overall idea is that by making well-curated datasets broadly usable through a central portal, Kids First can encourage cross-cutting analyses, collaboration across research groups, and ultimately advances that improve diagnosis and inform more targeted therapies.

The purpose of this specific R03 FOA is to fund small, clearly defined research projects that primarily analyze existing Kids First data rather than generating entirely new clinical trial outcomes. Projects are expected to focus on genomic datasets created through Kids First and/or linked phenotypic datasets that help interpret the genomic findings. In practical terms, applicants might propose studies that identify disease-associated variants, explore genotype-phenotype relationships, compare genetic architecture across cohorts, or refine subgroup definitions within childhood cancers or birth defects using integrated genomic and phenotypic information. The FOA also explicitly allows projects aimed at developing methods that are appropriate for these kinds of datasets, meaning applicants may propose new approaches, tools, pipelines, or algorithms for analyzing genomic, phenotypic, and/or clinical data relevant to Kids First, as long as the work is aligned with the program's mission and leverages the resource.

Because it is an R03, the intent is to support modestly scoped projects that can be completed with relatively limited funding and time, often serving as an entry point to test a promising analytic idea, produce preliminary results, or demonstrate feasibility that could later be scaled through larger mechanisms. The listed award ceiling is $200,000, which signals that budgets should be kept tight and aligned with a small-project footprint. This structure tends to favor proposals that are highly focused, with well-defined analytic aims, a clear plan for using Kids First datasets, and concrete expected outputs such as interpretable findings, validated analytic workflows, or reusable tools that benefit the broader community working with pediatric genomic data.

Eligibility is broad and includes many types of U.S. public entities and organizations as well as certain non-U.S. participants. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (outside of higher education); for-profit organizations (other than small businesses); small businesses; and other categories. The FOA also highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, tribal governments that are not federally recognized, non-domestic (non-U.S.) entities/foreign organizations, and U.S. territories or possessions. This broad eligibility is meant to encourage wide participation and to ensure that a diverse range of institutions and communities can contribute to and benefit from Kids First data-driven research.

Administrative details provided in the source include the agency (National Institutes of Health), the original closing date (2023-01-07), and the CFDA program numbers associated with the opportunity (93.121, 93.233, 93.394, 93.395, 93.837, 93.838, 93.839, 93.840, 93.865). Taken together, the grant supports small-scale but meaningful analytical or methodological work using the Kids First Data Resource, with the broader goal of turning shared pediatric genomic and phenotypic data into actionable biological insights that can move the field toward better diagnostics and more precise treatment strategies for childhood cancers and structural birth defects.

• The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Small Research Grants for Analyses of Gabriella Miller Kids First Pediatric Research Data (R03 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.233, 93.394, 93.395, 93.837, 93.838, 93.839, 93.840, 93.865.
• This funding opportunity was created on 2019-09-12.
• Applicants must submit their applications by 2023-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $200,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 19 375

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