Opportunity Information: Apply for HT9425 23 PRMRP LBIRA
The DoD Peer Reviewed Medical Research Program (PRMRP) Lifestyle and Behavioral Health Interventions Research Award (LBIRA), funding opportunity number HT9425 23 PRMRP LBIRA, is a Department of Defense grant/cooperative agreement mechanism managed through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It is designed to support clinical research and clinical trials that bring together multiple disciplines to address real-world health and disease challenges through lifestyle and behavioral health approaches. The program emphasizes the use of integrated expertise such as behavioral health and psychology, psychometrics, biostatistics, epidemiology, surveillance methods, and public health, reflecting an expectation that funded projects will be methodologically rigorous and clinically meaningful.
A core requirement is that each application must directly align with and propose a solution to one of the congressionally directed FY23 PRMRP Topic Areas and the FY23 PRMRP Strategic Goals. In practice, that means proposals cannot be purely exploratory or broadly framed; they need to be clearly anchored to the specific priority areas defined for that fiscal year and show how the work will advance those goals. The overarching intent of the LBIRA mechanism is to promote evidence-based, patient-centered interventions that measurably improve health outcomes, disease-related outcomes, and the overall patient experience in well-defined populations. The focus on "defined populations" signals that projects should specify who benefits (for example, a particular patient group, risk group, or community) and how outcomes will be captured in ways that matter to patients and care systems.
The types of research encouraged under this award include, but are not limited to, developing and testing lifestyle interventions and symptom-management strategies aimed at reducing disease risk and improving quality of life. It also supports studies that evaluate how prevention strategies, diagnostic approaches, treatments, or health care delivery models affect health outcomes, which can include clinical endpoints as well as patient-reported outcomes and functional measures. Another priority area is research exploring how behavioral, cognitive, and social functioning relates to the onset, progression, detection, treatment, and rehabilitation of a disease or condition, recognizing that these factors can shape both clinical trajectories and the effectiveness of interventions.
The opportunity further encourages studies that examine and improve quality of life and decision-making, which may include interventions or tools that help patients navigate care choices, adhere to treatments, or manage symptoms in everyday life. In addition, population-focused research is explicitly welcomed when it seeks to identify behavioral and lifestyle predictors of disease development or progression, supporting a broader public health perspective that can inform prevention and risk reduction strategies. Overall, the LBIRA mechanism targets applied, clinically grounded research that can generate actionable evidence for improving outcomes through behavioral and lifestyle interventions, while maintaining strict alignment with FY23 PRMRP priorities.
From an administrative standpoint, the opportunity is listed as discretionary funding, with awards made as either grants or cooperative agreements (the latter typically involving more substantial involvement by the funding agency during the project). Eligibility is listed as unrestricted, meaning it is broadly open to applicant types, subject to any additional eligibility clarifications in the full announcement. The CFDA number associated with the opportunity is 12.420. The posting indicates an expected five awards, with an original closing date of May 31, 2023, and a listed award ceiling of 0, which commonly indicates that the ceiling is not specified in the summary field and must be confirmed in the full funding announcement or related program guidance.Apply for HT9425 23 PRMRP LBIRA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Peer Reviewed Medical, Lifestyle and Behavioral Health Interventions Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Jan 31, 2023.
- Applicants must submit their applications by May 31, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DoD PRMRP Lifestyle and Behavioral Health Interventions Research Award (LBIRA)
What is this funding opportunity?
This opportunity is the Department of Defense (DoD) Peer Reviewed Medical Research Program (PRMRP) Lifestyle and Behavioral Health Interventions Research Award (LBIRA), funding opportunity number HT9425 23 PRMRP LBIRA. It is a grant/cooperative agreement mechanism managed through the U.S. Army Medical Research Acquisition Activity (USAMRAA).
What is the main purpose of the LBIRA mechanism?
The LBIRA mechanism is intended to support clinical research and clinical trials that use lifestyle and behavioral health approaches to address real-world health and disease challenges. The program is focused on evidence-based, patient-centered interventions that can measurably improve health outcomes, disease-related outcomes, and the overall patient experience in well-defined populations.
What types of projects does LBIRA support?
LBIRA supports applied, clinically grounded research, including clinical research and clinical trials, that evaluates lifestyle and behavioral health interventions. Projects are expected to produce actionable evidence that can improve outcomes through behavioral and lifestyle approaches.
Are clinical trials allowed or required?
Clinical trials are explicitly within scope. The mechanism is designed to support clinical research and clinical trials; the summary does not state that a trial is required for all applications, but it clearly allows them.
What disciplines or expertise are expected on the research team?
The program emphasizes integrated, multi-disciplinary expertise. Examples mentioned include behavioral health and psychology, psychometrics, biostatistics, epidemiology, surveillance methods, and public health. The expectation is that funded projects will be methodologically rigorous and clinically meaningful.
How important is alignment to PRMRP priorities?
Alignment is a core requirement. Each application must directly align with and propose a solution to one of the congressionally directed FY23 PRMRP Topic Areas and the FY23 PRMRP Strategic Goals. Proposals should be clearly anchored to those FY23 priorities rather than being broadly framed or purely exploratory.
Can a proposal be exploratory or broadly framed?
The summary indicates proposals cannot be purely exploratory or broadly framed. Applications need to be tied directly to an FY23 PRMRP Topic Area and show how the work advances FY23 PRMRP Strategic Goals.
What does "patient-centered" mean in the context of this award?
Based on the description provided, the award seeks interventions that improve outcomes that matter to patients and care systems, including health outcomes, disease-related outcomes, and the overall patient experience. The emphasis on measurable improvement suggests outcomes should be well-defined and clinically meaningful.
What does "well-defined populations" mean for applicants?
Projects should specify who will benefit from the intervention or approach (for example, a particular patient group, risk group, or community) and how outcomes will be captured in ways that matter to patients and care systems.
What kinds of outcomes are encouraged?
The opportunity highlights health outcomes and disease-related outcomes, and it also notes that studies may evaluate effects on clinical endpoints as well as patient-reported outcomes and functional measures. The overall theme is outcomes that are measurable and meaningful for patients and clinical decision-making.
What kinds of lifestyle and behavioral health research are explicitly encouraged?
Examples of encouraged research include:
- Developing and testing lifestyle interventions and symptom-management strategies to reduce disease risk and improve quality of life
- Evaluating how prevention strategies, diagnostic approaches, treatments, or health care delivery models affect health outcomes (including clinical endpoints, patient-reported outcomes, and functional measures)
- Studying how behavioral, cognitive, and social functioning relate to disease onset, progression, detection, treatment, and rehabilitation
- Examining and improving quality of life and decision-making (including interventions or tools supporting care choices, adherence, or day-to-day symptom management)
- Population-focused research to identify behavioral and lifestyle predictors of disease development or progression
Does the opportunity support research on health care delivery models?
Yes. The summary states that studies evaluating how prevention strategies, diagnostic approaches, treatments, or health care delivery models affect health outcomes are within scope.
Does the opportunity support research focused on decision-making or adherence?
Yes. The opportunity encourages studies that examine and improve quality of life and decision-making, including interventions or tools that help patients navigate care choices, adhere to treatments, or manage symptoms in everyday life.
Is population-focused or public health-oriented research allowed?
Yes. Population-focused research is explicitly welcomed when it seeks to identify behavioral and lifestyle predictors of disease development or progression, supporting prevention and risk reduction strategies.
What is the funding type for this opportunity?
The posting lists the opportunity as discretionary funding, with awards made as either grants or cooperative agreements.
What is the difference between a grant and a cooperative agreement in this posting?
The summary notes that a cooperative agreement typically involves more substantial involvement by the funding agency during the project, compared to a standard grant.
Who is eligible to apply?
Eligibility is listed as unrestricted, meaning it is broadly open to applicant types, subject to any additional eligibility clarifications that may exist in the full announcement.
How many awards are expected to be made?
The posting indicates an expected five awards.
What is the application deadline shown in the posting?
The original closing date listed is May 31, 2023.
Is there an award ceiling (maximum funding amount) listed?
The summary field shows an award ceiling of 0. This commonly indicates the ceiling is not specified in the summary and should be confirmed in the full funding announcement or related program guidance.
What is the CFDA number for this opportunity?
The CFDA number associated with the opportunity is 12.420.
What is USAMRAA's role in this opportunity?
USAMRAA manages this grant/cooperative agreement mechanism for the DoD PRMRP LBIRA opportunity.
What does "methodologically rigorous and clinically meaningful" imply for applications?
The program description emphasizes integrated expertise (for example, psychometrics, biostatistics, epidemiology, surveillance, and public health) and expects projects to be designed and executed in a way that produces robust, clinically relevant evidence rather than purely theoretical or exploratory findings.
Does the opportunity allow research related to behavioral, cognitive, and social functioning?
Yes. Research exploring how behavioral, cognitive, and social functioning relates to disease onset, progression, detection, treatment, and rehabilitation is specifically mentioned as a priority area within the scope of the award.
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