Opportunity Information: Apply for PA 16 442
The NIH grant opportunity "Changes in Cellular Architecture During Aging (R01)" (Funding Opportunity Number PA 16-442; CFDA 93.866) supports investigator-initiated research projects that use innovative approaches to better understand how the physical organization of cells changes as organisms age. The central focus is "cellular architecture," meaning how internal cell structures are built, maintained, and coordinated over time, and how age-related shifts in that organization may contribute to functional decline and disease. As an R01, this is intended for substantial, hypothesis-driven research programs rather than small pilot efforts, with an emphasis on mechanistic insight and strategies that can move the field forward.
Scientifically, the FOA highlights the cytoskeleton as a major area of interest. This includes studies on cytoskeletal structure and function (for example, how actin filaments, microtubules, and intermediate filaments are organized, remodeled, and stabilized in young versus aged cells), as well as work examining how the cytoskeleton influences interactions among intracellular organelles. The opportunity is also interested in signaling pathways and regulatory molecules that control cellular architecture, such as factors that govern cytoskeletal assembly/disassembly, crosslinking, transport dynamics, and cellular polarity. A specific priority area is understanding how the cytoskeleton contributes to nuclear-cytoplasmic communication, including how forces and signals are transmitted between the cytoplasm and nucleus during aging. The FOA also notes interest in spatio-temporal relationships, meaning where cellular components are located and how their positioning and dynamics change over time in aging cells, including in the context of age-related diseases.
Eligibility is broad and includes many U.S.-based organizational types: state, county, city, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education where relevant); for-profit organizations other than small businesses; small businesses; and other eligible entities. The FOA explicitly lists additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
There are also clear restrictions related to foreign involvement. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed under this announcement. The funding instrument is a discretionary NIH grant (R01). The source data indicates an original closing date of 2020-01-07 and a creation date of 2016-09-22; award ceiling and expected number of awards are not specified in the provided listing.Apply for PA 16 442
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Changes in Cellular Architecture During Aging (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2016-09-22.
- Applicants must submit their applications by 2020-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): Changes in Cellular Architecture During Aging (R01) - NIH (PA 16-442)
1) What is the name of this NIH funding opportunity?
The opportunity is titled "Changes in Cellular Architecture During Aging (R01)."
2) What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PA 16-442.
3) What is the CFDA number associated with this opportunity?
The listing identifies CFDA 93.866.
4) What type of grant mechanism is being used?
This opportunity uses the NIH R01 mechanism, described as a discretionary NIH grant.
5) What is the overall purpose of this FOA?
The FOA supports investigator-initiated research projects that use innovative approaches to better understand how the physical organization of cells changes as organisms age, and how age-related shifts in that organization may contribute to functional decline and disease.
6) What does the FOA mean by "cellular architecture"?
In this announcement, "cellular architecture" refers to how internal cell structures are built, maintained, and coordinated over time, including how that organization changes during aging.
7) What kinds of research projects are encouraged under an R01 for this topic?
The FOA positions this R01 as suitable for substantial, hypothesis-driven research programs rather than small pilot efforts, with an emphasis on mechanistic insight and strategies that can move the field forward.
8) Is the research expected to be mechanistic?
Yes. The provided description emphasizes mechanistic insight into how cellular architecture is regulated and how it changes with age.
9) What scientific area is highlighted as a major focus?
The FOA highlights the cytoskeleton as a major area of interest.
10) What cytoskeletal components are specifically mentioned?
Examples mentioned include actin filaments, microtubules, and intermediate filaments, particularly how they are organized, remodeled, and stabilized in young versus aged cells.
11) What types of cytoskeleton-focused questions fit this FOA?
Projects may examine cytoskeletal structure and function, including how the cytoskeleton is organized and remodeled with age, and how it affects intracellular organization and cellular function during aging.
12) Does the FOA include interest in interactions among intracellular organelles?
Yes. The FOA notes interest in work examining how the cytoskeleton influences interactions among intracellular organelles.
13) Are signaling pathways and regulatory molecules within scope?
Yes. The FOA explicitly mentions interest in signaling pathways and regulatory molecules that control cellular architecture.
14) What kinds of regulatory processes are called out?
Examples listed include factors that govern cytoskeletal assembly and disassembly, crosslinking, transport dynamics, and cellular polarity.
15) Is nuclear-cytoplasmic communication a priority area?
Yes. A specific priority area is understanding how the cytoskeleton contributes to nuclear-cytoplasmic communication during aging.
16) What does the FOA say about forces and signals between the cytoplasm and nucleus?
It is interested in how forces and signals are transmitted between the cytoplasm and nucleus during aging, in the context of cytoskeletal contributions.
17) Does the FOA mention spatio-temporal relationships in aging cells?
Yes. The FOA notes interest in spatio-temporal relationships, meaning where cellular components are located and how their positioning and dynamics change over time in aging cells.
18) Is the research limited to normal aging, or can it include age-related diseases?
The FOA indicates interest in these spatio-temporal and architectural changes in aging cells, including in the context of age-related diseases.
19) Who can apply for this FOA?
Eligibility is described as broad and includes many U.S.-based organization types, including various government entities, higher education institutions, nonprofits, and for-profit entities (including small businesses, and for-profits other than small businesses).
20) Are government entities eligible applicants?
Yes. The FOA lists state, county, city, and special district governments as eligible, as well as independent school districts and public housing authorities/Indian housing authorities.
21) Are institutions of higher education eligible?
Yes. The FOA includes public and state-controlled institutions of higher education and private institutions of higher education.
22) Are nonprofit organizations eligible?
Yes. The FOA includes nonprofits with and without 501(c)(3) status (excluding institutions of higher education where relevant, as stated in the eligibility list).
23) Are for-profit organizations eligible?
Yes. The FOA lists for-profit organizations other than small businesses, and also lists small businesses as eligible.
24) Are tribal governments and tribal organizations eligible?
Yes. The FOA includes federally recognized Native American tribal governments and tribal organizations that are not federally recognized.
25) Are U.S. territories or possessions eligible to apply?
Yes. The FOA explicitly lists U.S. territories or possessions among eligible applicant categories.
26) Are minority-serving and other specifically named institution types eligible?
Yes. The FOA explicitly lists categories including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, TCCUs, and other specified groups.
27) Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly includes faith-based or community-based organizations in the eligible applicant categories.
28) Are regional organizations eligible?
Yes. The FOA explicitly lists regional organizations as eligible.
29) Are eligible federal agencies allowed to apply?
Yes. The FOA explicitly includes eligible federal agencies.
30) Are foreign (non-U.S.) organizations eligible to apply?
No. The FOA states that non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply.
31) Can a U.S. organization apply if the project includes a non-domestic component?
No. The FOA indicates that non-domestic components of U.S. organizations are not eligible.
32) Are foreign components allowed under this announcement?
No. The FOA states that foreign components (as defined by NIH policy) are not allowed under this announcement.
33) What is the closing date shown in the source information provided?
The source data indicates an original closing date of 2020-01-07.
34) What is the creation date shown in the source information provided?
The source data indicates a creation date of 2016-09-22.
35) Does the provided listing specify an award ceiling?
No. The provided listing states that the award ceiling is not specified.
36) Does the provided listing state the expected number of awards?
No. The provided listing states that the expected number of awards is not specified.
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