Opportunity Information: Apply for W81XWH 19 PRMRP CTA
The CDMRP Peer Reviewed Medical Research Program (PRMRP) Clinical Trial Award is a Department of Defense funding opportunity aimed at moving clinical research quickly into real-world testing when there is a strong chance the results could meaningfully change care for patients. The program is specifically focused on clinical trials that address at least one of the Congressionally directed FY19 PRMRP Topic Areas, meaning applicants need to align their proposed trial with one or more of those designated disease or condition areas to be responsive. The intent is practical and impact-driven: support trials that can deliver clear evidence about whether an intervention works, how well it works, and in which patient populations it provides benefit.
This award supports a broad range of clinical trial designs, from early exploratory efforts through larger, more definitive studies. On the early end, it can include small proof-of-concept trials such as pilot studies, first-in-human studies, or Phase 0 trials, where the goal is often to demonstrate feasibility, gather initial safety or biological activity signals, refine procedures, and generate data that justify and shape subsequent, more advanced trials. On the later end, the program also allows for larger-scale trials intended to determine efficacy in relevant patient populations, which typically means evaluating clinical outcomes robustly enough to inform medical practice, guidelines, or further regulatory and implementation pathways.
The types of interventions that can be tested under this opportunity are intentionally wide-ranging. The announcement highlights trials evaluating promising new products, pharmacologic agents (including drugs or biologics), medical devices, clinical guidance, and emerging approaches or technologies. In practical terms, that scope could encompass testing a novel therapeutic, repurposing an existing drug for a new indication, evaluating a device-based intervention, validating a new clinical workflow or decision support approach, or assessing a technology-enabled method of delivering or monitoring care. What ties these together is the clinical trial requirement and the expectation that the work is positioned to create a significant impact on the targeted condition.
Administratively, this opportunity was released by the Department of Defense, Department of the Army, through the U.S. Army Medical Research Acquisition Activity (USAMRAA). The funding opportunity number is W81XWH 19 PRMRP CTA, and it falls under the Science and Technology and other Research and Development activity category, with CFDA number 12.420. The funding instruments listed are Cooperative Agreement and Grant, which signals that awards may be structured either as traditional grants or with a more collaborative federal role typical of cooperative agreements, depending on the needs and oversight requirements of the specific project. Eligibility is listed as unrestricted, meaning it is open to any type of entity, with the caveat that applicants must follow any additional eligibility clarifications that would appear in the full announcement text.
In terms of timing and scale, the opportunity was created on January 15, 2019, with an original closing date of July 2, 2019, and it anticipated making about 9 awards. The listed award ceiling is shown as 0, which typically indicates the public summary record does not specify a maximum dollar cap in that field, rather than implying no funds are available; the full solicitation would normally provide the actual budget limits, cost categories, and any constraints. Overall, the program is designed for teams that are ready to execute a clinical trial promptly and can justify why their study is positioned to produce actionable, high-value results for one of the FY19 PRMRP topic areas.Apply for W81XWH 19 PRMRP CTA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "CDMRP Peer Reviewed Medical Research Program Clinical Trial Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Jan 15, 2019.
- Applicants must submit their applications by Jul 02, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 9 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs)
What is the PRMRP Clinical Trial Award?
The CDMRP Peer Reviewed Medical Research Program (PRMRP) Clinical Trial Award is a U.S. Department of Defense funding opportunity intended to move clinical research into real-world testing quickly when the proposed study has a strong chance of producing results that could meaningfully change patient care.
What is the main purpose of this funding opportunity?
The intent is practical and impact-driven: to support clinical trials that can generate clear evidence about whether an intervention works, how well it works, and which patient populations benefit.
Does my project have to be a clinical trial to be responsive?
Yes. The opportunity is specifically described as a Clinical Trial Award and is focused on supporting clinical trials designed to evaluate interventions in real-world testing contexts.
What topic areas must the clinical trial address?
To be responsive, proposed trials must address at least one of the Congressionally directed FY19 PRMRP Topic Areas. Applicants need to align their trial with one or more of those designated disease or condition areas.
What kinds of clinical trial phases or stages are supported?
The award supports a broad range of clinical trial designs, from early exploratory efforts through larger, more definitive studies.
Are early-stage trials allowed under this award?
Yes. The opportunity includes early trials such as pilot studies, first-in-human studies, and Phase 0 trials. These early efforts may focus on feasibility, refining procedures, and gathering initial safety or biological activity signals to justify and shape later trials.
Are later-stage or larger efficacy trials allowed?
Yes. The program also allows for larger-scale trials intended to determine efficacy in relevant patient populations, including trials designed to evaluate clinical outcomes robustly enough to inform medical practice, guidelines, or subsequent regulatory or implementation pathways.
What types of interventions can be tested?
The scope of interventions is intentionally wide-ranging. The announcement highlights trials evaluating promising new products, pharmacologic agents (including drugs or biologics), medical devices, clinical guidance, and emerging approaches or technologies.
Does the opportunity allow testing of existing drugs for new uses?
Yes. The described scope includes repurposing an existing drug for a new indication as an example of the types of interventions that could be evaluated, as long as the work is structured as a clinical trial and aligned to an FY19 PRMRP Topic Area.
Can a project focus on validating clinical guidance or workflows?
Yes. The opportunity explicitly includes trials evaluating clinical guidance, and examples provided include validating a new clinical workflow or a decision support approach.
Can technology-enabled care delivery or monitoring approaches be included?
Yes. The scope includes emerging approaches or technologies, including technology-enabled methods of delivering or monitoring care, provided they are evaluated through a clinical trial and aligned to the required topic area(s).
Who released this funding opportunity?
The opportunity was released by the Department of Defense, Department of the Army, through the U.S. Army Medical Research Acquisition Activity (USAMRAA).
What is the funding opportunity number?
The funding opportunity number is W81XWH 19 PRMRP CTA.
What activity category does this opportunity fall under?
It falls under the Science and Technology and other Research and Development activity category.
What is the CFDA number for this opportunity?
The CFDA number listed is 12.420.
What funding instruments are used for awards under this opportunity?
The funding instruments listed are Cooperative Agreement and Grant. This indicates awards may be structured either as traditional grants or as cooperative agreements that involve a more collaborative federal role, depending on the project.
What does it mean that eligibility is "unrestricted"?
Eligibility is listed as unrestricted, meaning it is open to any type of entity. Applicants still need to follow any additional eligibility clarifications that would be provided in the full announcement.
When was this opportunity created and when did it close?
The opportunity was created on January 15, 2019, and the original closing date was July 2, 2019.
How many awards were anticipated?
The opportunity anticipated making about 9 awards.
Is there a maximum award amount (award ceiling)?
The listed award ceiling is shown as 0 in the summary record. This typically indicates the public summary field does not specify a maximum dollar cap there, rather than implying that no funds are available. The full solicitation would normally provide the actual budget limits and constraints.
What kind of applicant or team is this program designed for?
The program is designed for teams that are ready to execute a clinical trial promptly and can justify why their study is positioned to produce actionable, high-value results for one of the FY19 PRMRP topic areas.
What is the key expectation for impact?
The key expectation is that the proposed clinical trial is positioned to create a significant impact on the targeted condition and to deliver evidence that could meaningfully change care for patients.
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